Glucosamine-like supplement suppresses multiple sclerosis attacks

A glucosamine-like dietary supplement suppresses the damaging autoimmune response seen in multiple sclerosis, according to a UC Irvine study.

UCI's Dr. Michael Demetriou, Ani Grigorian and others found that oral N-acetylglucosamine (GlcNAc), which is similar to but more effective than the widely available glucosamine, inhibited the growth and function of abnormal T-cells that in MS incorrectly direct the immune system to attack and break down central nervous system tissue that insulates nerves.

Study results appear online in The Journal of Biological Chemistry.

Earlier this year, Demetriou and colleagues discovered that environmental and inherited risk factors associated with MS – previously poorly understood and not known to be connected – converge to affect how specific sugars are added to proteins regulating the disease.

"This sugar-based supplement corrects a genetic defect that induces cells to attack the body in MS," said Demetriou, associate professor of neurology and microbiology & molecular genetics, "making metabolic therapy a rational approach that differs significantly from currently available treatments."

Virtually all proteins on the surface of cells, including immune cells such as T-cells, are modified by complex sugar molecules of variable sizes and composition. Recent studies have linked changes in these sugars to T-cell hyperactivity and autoimmune disease.

In mouse models of MS-like autoimmune disease, Demetriou and his team found that GlcNAc given orally to those with leg weakness suppressed T-cell hyperactivity and autoimmune response by increasing sugar modifications to the T-cell proteins, thereby reversing the progression to paralysis.

The study comes on the heels of others showing the potential of GlcNAc in humans. One reported that eight of 12 children with treatment-resistant autoimmune inflammatory bowel disease improved significantly after two years of GlcNAc therapy. No serious adverse side effects were noted.

"Together, these findings identify metabolic therapy using dietary supplements such as GlcNAc as a possible treatment for autoimmune diseases," said Demetriou, associate director of UCI's Multiple Sclerosis Research Center. "Excitement about this strategy stems from the novel mechanism for affecting T-cell function and autoimmunity – the targeting of a molecular defect promoting disease – and its availability and simplicity."

He cautioned that more human studies are required to assess the full potential of the approach. GlcNAc supplements are available over the counter and differ from commercially popular glucosamine. People who purchase GlcNAc should consult with their doctors before use.

Provided by University of California - Irvine

A new detection system can reveal bioterrorist attacks on our water supply network

 

If pathogens enter into our water supply network many people may fall ill quickly. To protect us against this biological threat, researchers have developed a detection system partly based on nanotechnology that can warn authorities in time.

In the 21st century several countries have suffered great losses after terrorist attacks. Although the risk of bioterrorist attacks or accidental contamination of our water supply network is low, the consequences could be fatal. Researchers connected to DINAMICS (DIagnostic NAnotech and MICrotech Sensors), a project co-funded by the European commission, have made a lab-on-a-chip device that can monitor our drinking water and spot different pathogens even at very low concentrations.

The device uses sensors with very small strands of different pathogenic DNA integrated onto their surfaces to quickly recognize pathogenic DNA from water samples. The DNA in the sensors will only bind to the water samples’ corresponding DNA, multiplied for easier identification. To see what different DNAs are present in the water samples, the researchers apply a reaction called chemiluminescence that will make the bound DNAs emit light. The nanoscale reactions are then interpreted by a computer. The DINAMICS project’s researchers have also developed another type of sensor that changes the bound DNAs into electric signals. The signal’s magnitude is proportional to the quantity of pathogenic DNA from the water sample.

At present, water samples are brought to the laboratory for analysis. The researchers’ goal is to make this step redundant by bringing the laboratory to the water instead, since the device is part of a portable detection system. This would speed up the process substantially. If the system detects a biological threat the authorities can be informed through email or mobile phone.

Another way of spotting accidental or deliberate water contamination has been developed by the Fraunhofer Institute in Germany. By also recognizing that existing methods for water analysis are time-consuming they have set up a system called AquaBioTox, which uses living microorganisms. A sensitive camera system continuously records and analyses the microorganisms’ reactions to the water. Even though the researchers have documented a reliable and fast detection of contaminants, to guarantee robustness against false alarm and maximum reliability in diagnosis they recommend that the system is combined with other sensors on the market.

The DINAMICS project is planned to end the last day of March and if the system becomes widely available in the water industry this more cost-efficient way of testing could significantly improve water safety, alone or in combination with other sensors.

Provided by Youris.com (news : web)