Thermo Fisher Scientific Announces New Method for Low Level Detection of Volatile Nitrosamines in Tobacco

 Thermo Fisher Scientific Inc. announced a new comprehensive method that uses triple quadrupole GC-MS/MS to achieve lower levels of detection of volatile nitrosamines (VNA) in tobacco. The new method allows environmental laboratories, tobacco companies and government agencies to efficiently separate VNAs while lowering detection limits, increasing specificity and enabling the analysis of many other contaminants in tobacco, including pesticides. The new method is detailed in an application note entitled “Lower Detection Limits of Volatile Nitrosamines in Tobacco by Triple Quadrupole GC-MS/MS,”.

Volatile nitrosamines are a class of compounds that can form in tobacco smoke, as well as during the curing and processing of tobacco. These compounds have been proven to have adverse effects on human health; and two of the VNAs found in tobacco, N-nitrosodiethylamine (NDEA) and N-nitrosodimethylamine (NDMA), are classed as known human carcinogens by regulatory authorities. As a result, these compounds must be thoroughly monitored in order to safeguard human health and comply with increasingly stringent regulations.

The new Thermo Fisher method is a powerful alternative to other traditionally used techniques. By coupling a gas chromatograph to a triple quadrupole mass spectrometer, the new method makes detection limits of 1ng/mL achievable, enabling users to satisfy the increasingly lower detection limits required by governments and regulatory bodies. The method also increases contaminant specificity within a classification and allows many other organic contaminants and chemicals in tobacco to be analyzed simultaneously, including pesticides.

The new method includes GC-MS/MS analysis on the Thermo Scientific TSQ Quantum XLS triple quadrupole GC-MS/MS system using timed selected reaction monitoring (t-SRM). This unique feature enables easy method set-up and allows users to run samples while the instrument automatically determines the optimal time for SRM parameters.

Thermo Fisher Scientific Presents $35,000 Distinguished Research Award to Dr. Judit Villen, University of Washington

Thermo Fisher Scientific Inc. announced that it has presented Dr. Judit Villen of the University of Washington, Seattle, with the American Society for Mass Spectrometry (ASMS) 2011 Research Award of $35,000. Sponsored by Thermo Fisher Scientific for more than 20 years and administered by ASMS, the annual award recognizes and supports breakthrough academic research by young scientists in the field of mass spectrometry (MS). The award has propelled many past recipients to leadership positions in MS research. Dr. Villen received the award during a ceremony at the Wells Fargo Theatre in Denver during the 2011 ASMS conference.

An independent and anonymous ASMS committee chose Dr. Villen based on her research on the MS-based analysis of protein phosphorylation in single cells. Her goal is to understand the complex cellular signaling networks that impact the expression of cancers such as human breast cancer. The early-stage research, which the award will support, focuses on the development of a novel interface for single-cell MS using a Thermo Scientific Orbitrap hybrid mass spectrometer system. Dr. Villen will use her award to purchase laboratory supplies and equipment and, if necessary, to pay graduate student or supplement post-doctoral salaries.

“Until now, MS studies measured proteins based on the average of millions of cells, completely missing the variations between individual cells that can have substantial consequences in signaling cell growth, proliferation and differentiation, all of which play roles in the expression of diseases such as cancer,” said Dr. Ian Jardine, vice president of global R&D, Thermo Fisher Scientific. “Through her early-stage effort to develop an interface for single-cell mass spectrometry analysis, Dr. Villen will launch an exciting new era of single-cell proteomics.”

Dr. Villen joined the University of Washington as an assistant professor in the Genome Sciences Department in June 2010. Her accomplishments include contributions to numerous scientific publications, invitations to speak at meetings and conferences such as ASMS, and industry patents. Dr. Villen also received the 2009 Howard Termin Pathway to Independence Award in Cancer Research from the National Cancer Institute (NCI) of the National Institutes of Health (NIH).